This occurred despite the fact that mice on a low carbohydrate diet had gained comparatively less weight than
mice on a regular 'balanced' diet.
The low carbohydrate diet was found to undermine the body's ability to recover from a heart attack,
by preventing the formation of new blood vessels in tissues deprived of blood flow.
The study also found that the standard indicators of heart disease,
including cholesterol,
did not change in mice that were fed a diet low in carbohydrates, despite evidence
pointing to an increase in plaque in the arteries.
"It's very difficult to know in clinical studies how diets affect vascular health,"
said senior author Dr Anthony Rosenzweig, Director of Cardiovascular Research
in Beth Israel Deaconess Medical Center in Boston.
Doctors have until now relied on indicators like cholesterol, which support the positive benefits
of a low carbohydrate diet high in protein, because dieters tend to lose weight. However,
this study suggests that in mice, this kind of diet has a negative effect on health that is not
reflected in indicators like cholesterol.
"Understanding the mechanisms responsible for these effects, as well as the potential restorative capacity
that may counteract vascular disease, could ultimately help guide doctors in advising their patients,"
Dr Rosenzweig said.
"For now, it appears that a moderate and balanced diet, coupled with regular exercise,
is probably best for most people.
Source:-Dr Rosenzweig This study was published in the online version of the
Proceedings of the National Academy of Sciences
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